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Such a quadruplex is described as tetramolecular, reflecting the requirement of four separate strands. The term G4 DNA was originally reserved for these tetramolecular structures that might play a role in meiosis. [5] However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity.
DNAzyme research for the treatment of cancer is also underway. The development of a 10-23 DNAzyme that can block the expression of IGF-I (Insulin-like growth factor I, a contributor to normal cell growth as well as tumorigenesis) by targeting its mRNA could be useful for blocking the secretion of IGF-I from prostate storm primary cells ...
In biochemistry, a zymogen (/ ˈ z aɪ m ə dʒ ən,-m oʊ-/ [1] [2]), also called a proenzyme (/ ˌ p r oʊ ˈ ɛ n z aɪ m / [3] [4]), is an inactive precursor of an enzyme.A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme.
Hoogsteen pairs have quite different properties from Watson–Crick base pairs.The angle between the two glycosidic bonds (ca. 80° in the A• T pair) is larger and the C1 ′ –C1 ′ distance (ca. 860 pm or 8.6 Å) is smaller than in the regular geometry.
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Among others, Zwicky applied morphological analysis to astronomical studies and jet and rocket propulsion systems. As a problem-structuring and problem-solving technique, morphological analysis was designed for multi-dimensional, non-quantifiable problems where causal modelling and simulation do not function well, or at all.
To change this template's initial visibility, the |state= parameter may be used: {{G4 Original Broadcast Line-up | state = collapsed}} will show the template collapsed, i.e. hidden apart from its title bar. {{G4 Original Broadcast Line-up | state = expanded}} will show the template expanded, i.e. fully visible.
There are also two SL only courses: a transdisciplinary course, Environmental Systems and Societies, that satisfies Diploma requirements for Groups 3 and 4, [2] and Sports, Exercise and Health Science (previously, for last examinations in 2013, a pilot subject [3]). Astronomy also exists as a school-based syllabus.