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Unlike other antidepressants, bupropion is known to cause fewer and less severe adverse symptoms, like drowsiness, weight loss, weight gain and intimate dysfunction.
Experiments with pharmacological agents that cause depletion of monoamines have shown that this depletion does not cause depression in healthy people. [ 56 ] [ 57 ] Another problem that presents is that drugs that deplete monoamines may actually have antidepressants properties.
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]
Also, currently available antidepressants all elicit undesirable side-effects, and new agents should be divested of the distressing side-effects of both first and second-generation antidepressants. [6] Another serious drawback of all antidepressants is the requirement for long-term administration prior to maximal therapeutic efficacy.
Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as erectile dysfunction ...
Vitamin B12 supplements might be better for folks with metabolic syndrome or those who have a deficiency. More research is needed to know if vitamin B12 is an effective weight loss aid.
A 2006 review suggests that the widespread use of antidepressants in the new "SSRI-era" appears to have led to a highly significant decline in suicide rates in most countries with traditionally high baseline suicide rates. The decline is particularly striking for women who, compared with men, seek more help for depression.
As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight U.S. adults takes antidepressants—scientists have been innovating novel treatments for it.
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