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The Crypts of Lieberkühn (intestinal glands) are named for him; he first described these in detail in De fabrica et actione vollorum intestinorum tenuium hominis, in 1745. Beyond this, Lieberkühn produced optical instruments such as compass microscopes with Lieberkühn reflector , further developing the light microscope , which he had seen ...
Cells are produced at the crypt base and migrate upward along the crypt axis before being shed into the colonic lumen days later. [8] There are 5 to 6 stem cells at the bases of the crypts. [8] As estimated from the image in panel A, there are about 100 colonic crypts per square millimeter of the colonic epithelium. [10]
Leeuwenhoek and Kircher used a "simple microscope" for their work. A special form of the simple microscope was the compass microscope, which was built from the end of the 17th century. Like a pair of compasses, it had two legs, the distance between which could be adjusted in fine steps. On one leg was the objective lens, and the specimen was ...
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Lysozyme is an antimicrobial enzyme that dissolves the cell walls of many bacteria, and phospholipase A2 is an enzyme specialized in the lysis of bacterial phospholipids. [10] This battery of secretory molecules gives Paneth cells a potent arsenal against a broad spectrum of agents, including bacteria, fungi and even some enveloped viruses .
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Crypts are anatomical structures that are narrow but deep invaginations into a larger structure. One common type of anatomical crypt is the Crypts of Lieberkühn. [1] However, it is not the only type: some types of tonsils also have crypts. Because these crypts allow external access to the deep portions of the tonsils, these tonsils are more ...