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Very rarely Stevens–Johnson syndrome, liver damage, severe allergy has been reported [17] May lower blood sugar excessively in combination with diabetes medication. [17] Contains a chemical linked to possible birth defects. [17]
Alpha-glucosidase inhibitors (AGIs) are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar). They are found in raw plants/herbs such as cinnamon and bacteria (containing the inhibitor acarbose ).
The mechanisms underlying most herb-drug interactions are not fully understood. [25] Interactions between herbal medicines and anticancer drugs typically involve enzymes that metabolize cytochrome P450. [23] For example, St. John's Wort has been shown to induce CYP3A4 and P-glycoprotein in vitro and in vivo. [23]
WHODrug concepts can be organized into groups. Standardised Drug Groupings (SDGs) define groups of drugs. For example, diuretics, corticosteroids, drugs used in diabetes. Groups are also defined based on interaction, for example, drugs interacting with CYP2C8 or drugs interacting with UGT. R,Lee [4]
The root is used in decoctions against fevers, diabetes, diseases of urinary system and constipation. The leaves have laxative properties. The dried flowers and flower buds are used as a substitute for tea in case of diabetes patients. The powdered seed is also applied to the eye, in case of chronic purulent conjunctivitis. [citation needed]
Grapefruit–drug interactions that affect the pre-systemic metabolism (i.e., the metabolism that occurs before the drug enters the blood) of drugs have a different duration of action than interactions that work by other mechanisms, such as on absorption, discussed below.
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