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  2. Ristocetin-induced platelet aggregation - Wikipedia

    en.wikipedia.org/wiki/Ristocetin-induced...

    The ristocetin-induced platelet aggregation (RIPA) is an ex vivo assay for live platelet function. It measures platelet aggregation with the help of von Willebrand factor (vWF) and exogenous antibiotic ristocetin added in a graded fashion. [ 1 ]

  3. Ristocetin - Wikipedia

    en.wikipedia.org/wiki/Ristocetin

    In some types of vWD (types 2B and platelet-type), even very small amounts of ristocetin cause platelet aggregation when the patient's platelet-rich plasma is used. [1] This paradox is explained by these types having gain-of-function mutations which cause the vWD high molecular-weight multimers to bind more tightly to their receptors on ...

  4. Thromboregulation - Wikipedia

    en.wikipedia.org/wiki/Thromboregulation

    Platelet aggregation plays a critical role in the genesis of a resulting thrombus. Adhesion should remain local, but platelet aggregation must grow exponentially to form a platelet thrombus and prevent blood loss. Platelet aggregation factors are the regulators that enhance the adhesion and stimulate the platelets to secrete its granules.

  5. Multiple electrode aggregometry - Wikipedia

    en.wikipedia.org/wiki/Multiple_electrode...

    [8] [9] 300 μL of blood is needed for each analysis, and is diluted with the same amount of saline. After pipetting blood and saline into the cuvette, the test is incubated for three minutes before the chosen agonist is added. The test is then started, and platelet aggregation is recorded at approximately 0.5 second intervals for six minutes.

  6. Platelet membrane glycoprotein - Wikipedia

    en.wikipedia.org/wiki/Platelet_membrane_glycoprotein

    This complex interacts with fibrinogen and thus plays an important role in platelet aggregation and adhesion to endothelial surfaces. Activation of this complex initiates the platelet aggregation and the formation of primary platelet plug, a fibrin clot. The IIb / IIIa complex is a major platelet membrane component. There are as many as 50 000 ...

  7. Glanzmann's thrombasthenia - Wikipedia

    en.wikipedia.org/wiki/Glanzmann's_thrombasthenia

    Glanzmann's thrombasthenia is an abnormality of the platelets. [2] It is an extremely rare coagulopathy (bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen.

  8. Kelly Ripa Gives Major Health Update After Missing ‘Live’

    www.aol.com/kelly-ripa-gives-major-health...

    Kelly Ripa finally returned to Live with Kelly and Mark on Monday, December 4 after being out sick last week. The host, who was greeted with a ton of applause when she took the stage, ...

  9. Coagulation activation marker - Wikipedia

    en.wikipedia.org/wiki/Coagulation_activation_marker

    Coagulation activation markers are biomarkers of net activation of coagulation and fibrinolysis. [1] [2] Examples include prothrombin fragment 1+2 (F1+2), thrombin–antithrombin complex (TAT), fibrinopeptide A (FpA), fibrin monomers (FMs), plasmin-α 2-antiplasmin complex (PAP), activated protein C–protein C inhibitor (APC-PCI), and D-dimer (DD).

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