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Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. [3] Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. [3]
Lehmann and Neumann, 1896. Streptococcus agalactiae (also known as group B streptococcus or GBS) is a gram-positive coccus (round bacterium) with a tendency to form chains (as reflected by the genus name Streptococcus). It is a beta- hemolytic, catalase -negative, and facultative anaerobe. [1][2]
Sabine Moussier, Mexican actress [24] Lena Nyman, Swedish actress. Lucky Oceans, Grammy Award -winning musician with Asleep at the Wheel, was diagnosed with GBS in 2008. [25] Len Pasquarelli, sports writer and analyst for ESPN and resident of the Pro Football Writers of America, was diagnosed in 2008. [26]
Franklin D. Roosevelt, later the 32nd president of the United States from 1933 to 1945, began experiencing symptoms of a paralytic illness in 1921 when he was 39 years old. His main symptoms were fevers; symmetric, ascending paralysis; facial paralysis; bowel and bladder dysfunction; numbness and hyperesthesia; and a descending pattern of recovery.
Specialty. Neurology. Acute motor axonal neuropathy (AMAN) is a variant of Guillain–Barré syndrome. It is characterized by acute paralysis and loss of reflexes without sensory loss. Pathologically, there is motor axonal degeneration with antibody-mediated attacks of motor nerves and nodes of Ranvier. [citation needed]
Treatment. Immunotherapy. [2] Bickerstaff brainstem encephalitis is a rare inflammatory disorder of the central nervous system, [3] first described by Edwin Bickerstaff in 1951. [4][5] It may also affect the peripheral nervous system, and has features in common with both Miller Fisher syndrome and Guillain–Barré syndrome.
Streptococcus agalactiae is the most common human pathogen belonging to group B of the Lancefield classification of streptococci —hence the name of group B stretococcal (GBS). Infection with GBS can cause serious illness and sometimes death, especially in newborns, the elderly, and people with compromised immune systems.
Pfizer (PFE) gets Breakthrough Therapy Designation for GBS vaccine candidate, GBS6, based on an interim analysis of a phase II study.
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