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Thromboplastin. Thromboplastin (TPL) is derived from cell membranes and is a mixture of both phospholipids and tissue factor, neither of which are enzymes. Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, [1] aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin.
Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. Prothrombin is produced in the liver and is co-translationally modified in a vitamin K -dependent reaction that converts 10 ...
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of ...
A first-of-its-kind case study has highlighted the ways in which the brain changes throughout pregnancy, ... In both cases, this adaptive process enables the brain to become more specialized.” ...
Some parts of the brain go through major changes during pregnancy and only a few regions remain untouched, the first map of the process suggests. MRI scans taken before conception, throughout ...
Prothrombin activator. Prothrombin activator is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin. Prothrombin activator is released in the body by a cascade of chemical reactions in response to damage in a blood vessel.
Certain brain regions may shrink in size during pregnancy yet improve in connectivity, “with only a few regions of the brain remaining untouched by the transition to motherhood,” according to ...
An ultrasound image demonstrating a blood clot in the left common femoral vein. Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). [1][2] Such abnormalities can be identified in 50% of people who have an episode ...