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  2. Homeostasis - Wikipedia

    en.wikipedia.org/wiki/Homeostasis

    The effector tissue is the red bone marrow which produces red blood cells (RBCs, also called erythrocytes). The increase in RBCs leads to an increased hematocrit in the blood, and a subsequent increase in hemoglobin that increases the oxygen carrying capacity.

  3. Extramedullary hematopoiesis - Wikipedia

    en.wikipedia.org/wiki/Extramedullary_hematopoiesis

    In adults, the majority of hematopoiesis occurs in the bone marrow. Significant production in any other organ is usually the result of a pathological process. When red blood cell (RBC) numbers are low, the body induces a homeostatic mechanism aimed to increase the synthesis of RBCs, typically via the production of erythropoietin. If the loss of ...

  4. Renal osteodystrophy - Wikipedia

    en.wikipedia.org/wiki/Renal_osteodystrophy

    Renal osteodystrophy is currently defined as an alteration of bone morphology in patients with chronic kidney disease (CKD). [1] It is one measure of the skeletal component of the systemic disorder of chronic kidney disease-mineral and bone disorder (CKD-MBD). [1][2][3] The term "renal osteodystrophy" was coined in 1943, [4] 60 years after an ...

  5. Chronic kidney disease–mineral and bone disorder - Wikipedia

    en.wikipedia.org/wiki/Chronic_kidney_disease...

    Chronic kidney disease–mineral and bone disorder (CKD–MBD) is one of the many complications associated with chronic kidney disease. It represents a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: [1][2] Abnormalities of calcium, phosphorus (phosphate), parathyroid ...

  6. Bone marrow failure - Wikipedia

    en.wikipedia.org/wiki/Bone_marrow_failure

    Bone marrow failure occurs in individuals who produce an insufficient amount of red blood cells, white blood cells or platelets. Red blood cells transport oxygen to be distributed throughout the body's tissue. White blood cells fight off infections that enter the body. Bone marrow progenitor cells known as megakaryocytes produce platelets ...

  7. Bone hemostasis - Wikipedia

    en.wikipedia.org/wiki/Bone_hemostasis

    Bone hemostasis is the process of controlling the bleeding from bone . Bone is a living vascular organ containing channels for blood and bone marrow. [ 1] When a bone is cut during surgery bleeding can be a difficult problem to control, especially in the highly vascular bones of the spine and sternum. Bleeding from soft tissue is normally ...

  8. Hematopoietic stem cell transplantation - Wikipedia

    en.wikipedia.org/wiki/Hematopoietic_stem_cell...

    Hematopoietic stem cell transplantation. Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells. [1][2][3][4][5][6] HSCT may be ...

  9. High-dose chemotherapy and bone marrow transplant - Wikipedia

    en.wikipedia.org/wiki/High-dose_chemotherapy_and...

    The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. Chronic consequences of the treatment included development of leukemias and lymphomas and heightened ...

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