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Along with the UK Cochrane Centre, the centre was originally created as part of the Information Systems Strategy of the NHS Research and Development Programme. The original aims of the centre were: To carry out and commission systematic reviews of research findings on the effectiveness and cost effectiveness of health care relevant to the NHS
There is ongoing research into several potential benefits of candesartan beyond established indications. Candesartan is being investigated for its neuroprotective and anti-inflammatory properties. In an early Alzheimer's disease mouse model , candesartan significantly reduced amyloid burden and inflammation [ 22 ] and it is being examined as a ...
The National Research Ethics Service (NRES) is a UK medical quango which deals with research ethics. Principal Investigators must describe the experiment they intend to pursue to the NRES for its approval, failing which the study is prohibited.
This extended its remit to include safety in medical research, through the Central Office for Research Ethics Committees (COREC). Between 2005 and April 2012 it hosted the National Clinical Assessment Service that aims to help in resolving concerns about the performance of individual doctors and dentists. [ 3 ]
A series of unsuccessful and ineffective clinical trials in the past were the main reason for the creation of ICH and GCP guidelines in the US and Europe. These discussions ultimately led to the development of certain regulations and guidelines, which evolved into the code of practice for international consistency of quality research.
Health Research Authority logo. The Health Research Authority (HRA) is an arm's length body of the Department of Health and Social Care (DHSC) in England. [1] The HRA exists to provide a unified national system for the governance of health research. The current chair of the HRA is Professor Sir Terence Stephenson, who succeeded Sir Jonathan ...
An institutional review board (IRB), also known as an independent ethics committee (IEC), ethical review board (ERB), or research ethics board (REB), is a committee at an institution that applies research ethics by reviewing the methods proposed for research involving human subjects, to ensure that the projects are ethical. The main goal of IRB ...
[8] Candesartan is used experimentally in preventive treatment of migraine. [9] [10] Lisinopril has been found less often effective than candesartan at preventing migraine. [11] The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [12]