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The Clinical Practice Research Datalink (CPRD) is an observational and interventional research service that operates as part of the Department of Health and Social Care.It is jointly funded by the National Institute for Health and Care Research (NIHR) and the Medicines and Healthcare products Regulatory Agency (MHRA).
Along with the UK Cochrane Centre, the centre was originally created as part of the Information Systems Strategy of the NHS Research and Development Programme. The original aims of the centre were: To carry out and commission systematic reviews of research findings on the effectiveness and cost effectiveness of health care relevant to the NHS
There is ongoing research into several potential benefits of candesartan beyond established indications. Candesartan is being investigated for its neuroprotective and anti-inflammatory properties. In an early Alzheimer's disease mouse model , candesartan significantly reduced amyloid burden and inflammation [ 22 ] and it is being examined as a ...
[8] Candesartan is used experimentally in preventive treatment of migraine. [9] [10] Lisinopril has been found less often effective than candesartan at preventing migraine. [11] The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [12]
The NIHR (originally named National Institute for Health Research) was created in April 2006 under the government's health research strategy, Best Research for Best Health. [7] This strategy outlined the direction that NIHR research and development should take. Its predecessor was the NHS Research & Development programme which was established ...
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
Amongst patients and the general public concerns have been raised about sale of NHS data to private companies. [4] [5]The Pulse magazine - distributed to general practitioners in the UK, carried articles reflecting concern about the scope of the data being collected [6] and the additional workload and legal risks it would impose on GPs [7]
The first version was developed in the early 1980s by Dr James Read, a Loughborough general medical practitioner. [2] The scheme was structured similarly to ICD-9: . each code was composed of four consecutive characters: first character 0-9, A-Z (excepting I and O), remaining three characters 0-9, A-Z/a-z (excepting i,I,o and O) plus up to three trailing period '.' characters