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In effect, he argues that naltrexone-induced opioid antagonism sufficiently disrupts reflexive reward mechanisms inherent in the consumption of alcohol and, given enough repetition, will dissociate positive associations formerly made with the consumption of alcohol. The Sinclair Method has a clinically proven success rate of 78%. [27]
John David Sinclair (March 28, 1943 – April 6, 2015) was an American scientist and researcher best known for discovering the Alcohol Deprivation Effect (ADE) and targeted pharmacological extinction, otherwise known as the Sinclair Method, as a medication treatment for Alcohol Use Disorder (AUD).
One Little Pill is a documentary film about the Sinclair method of treating alcohol abuse. [2] The film follows the lives of several people who have suffered from alcoholism, and have been helped by the treatment. Perspectives from scientists, treatment centers, doctors, and a legal prosecutor are also presented.
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The Fasting Cure is a 1911 nonfiction book on fasting by Upton Sinclair. It is a reprinting of two articles written by Sinclair which were originally published in the Cosmopolitan magazine. It also includes comments and notes to the articles, as well as extracts of articles Sinclair published in the Physical Culture magazine.
In 1969, the government owned Alko Labs - currently the National Public Health and Welfare Institute, Helsinki - recruited Dr. David Sinclair from the University of Oregon after his publications on the Alcohol Deprivation Effect [1] with the first human trials using naltrexone and nalmefene starting in the mid 1990s.
A new survey found that 1 in 5 adults “who say they have no personal or family history of heart attack or stroke,” reported “routinely” taking a low-dose aspirin
The content in WP about the Sinclair Method is in the section mentioned above: "The Sinclair method is a method of using opiate antagonists to treat alcoholism by having the person take the medication about an hour before they drink alcohol, and only then.
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