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A peptidergic agent (or drug) is a chemical which functions to directly modulate the peptide systems in the body or brain. An example is opioidergics, which are neuropeptidergics. A cell-penetrating peptide is a peptide able to penetrate the cell membrane.
Redd says animal products including meat, milk and eggs "are the best sources" of peptides. Beyond animal sources, plant-based sources such as legumes, flax seeds, hemp seeds, soybeans, oats and ...
For example, these constructs have been shown to play important roles in fertilization, [1] the immune system, [2] brain development, [3] the endocrine system, [3] and inflammation. [ 3 ] [ 4 ] [ 5 ] The synthesis of glycopeptides provides biological probes for researchers to elucidate glycan function in nature and products that have useful ...
Peptide-gated ion channels (FMRFamide-gated sodium channels) have been found in snails and Hydra. [11] Other examples of non-GPCR targets include: insulin-like peptides and tyrosine-kinase receptors in Drosophila and atrial natriuretic peptide and eclosion hormone with membrane-bound guanylyl cyclase receptors in mammals and insects. [12]
[36]: 19 The peptide bond has two resonance forms that confer some double-bond character to the backbone. The alpha carbons are roughly coplanar with the nitrogen and the carbonyl (C=O) group. The other two dihedral angles in the peptide bond determine the local shape assumed by the protein backbone. One conseqence of the N-C(O) double bond ...
Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases. Naturally occurring peptides may serve as hormones , growth factors , neurotransmitters , ion channel ligands , and anti-infectives ; peptide therapeutics mimic such functions.
The peptide goes into the endoplasmic reticulum for post-translational processing. It is directed there by a signal recognition particle on the endoplasmic reticulum, which recognizes the peptide's N-terminal signal sequence (the early part of the sequence). The processed product is a pre-pro-peptide called preprocollagen.
(A) Representative examples of lasso peptide biosynthetic gene clusters. Arrows depicting open reading frames are shown with lengths proportional to gene size, as indicated by the scale bar. Genes are color coded and labeled according to function. (B) General scheme of lasso peptide biosynthesis.