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In genetics, a transcription terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription.This sequence mediates transcriptional termination by providing signals in the newly synthesized transcript RNA that trigger processes which release the transcript RNA from the transcriptional complex.
Tus, also known as terminus utilization substance, is a protein that binds to terminator sequences and acts as a counter-helicase when it comes in contact with an advancing helicase. [2] The bound Tus protein effectively halts DNA polymerase movement. [2] Tus helps end DNA replication in prokaryotes. [2]
Intrinsic terminator containing an RNA hairpin rich in guanine and cytosine as well as a region high in uracil. The two types of termination signals in bacteria are intrinsic and factor-dependent terminators. [4] Intrinsic termination occurs when a specific sequence on the growing RNA strand elicits detachment of RNA polymerase from the RNA-DNA ...
Terminator hairpin (Thp) Nucleation; hairpin completion and elongation complex inactivation; elongation complex dissociation A complete mechanism is likely to involve specific interactions of the polymerase, the RNA terminator hairpin, and dT-rich template sequences.
Terminator is an American media franchise created by James Cameron and Gale Anne Hurd.It is considered to be of the cyberpunk subgenre of science fiction. [4] [5] The franchise primarily focuses on a post-apocalyptic war between a synthetic intelligence known as Skynet, and a surviving resistance of humans led by John Connor.
They are required for the termination of DNA replication and function by binding to DNA replication terminator sequences, thus preventing the passage of replication forks. [1] The termination efficiency is affected by the affinity of a particular protein for the terminator sequence .
Rho factor binds to the transcription terminator pause site, an exposed region of single stranded RNA (a stretch of 72 nucleotides) after the open reading frame at C-rich/G-poor sequences that lack obvious secondary structure. [2] Rho factor is an essential transcription protein in bacteria. [3]
A regulatory sequence is a segment of a nucleic acid molecule which is capable of increasing or decreasing the expression of specific genes within an organism. Regulation of gene expression is an essential feature of all living organisms and viruses.