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Naphthoylindoles: Any compound containing a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any ...
5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one (DMPC) is a derivative of oroxylin A. It has memory improving effects and can reduce ADHD-like behavior. It has memory improving effects and can reduce ADHD-like behavior.
Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine.The main feature differentiating phenyltropanes from cocaine is that they lack the ester functionality at the 3-position terminating in the benzene; and thusly the phenyl is attached direct to the tropane skeleton with no further spacer (therefore the name "phenyl"-tropane) that ...
Indole can also be metabolized by the liver into indoxyl sulfate, a compound that is toxic in high concentrations and associated with vascular disease and renal dysfunction. [2] AST-120 ( activated charcoal ), an intestinal sorbent that is taken by mouth , adsorbs indole, in turn decreasing the concentration of indoxyl sulfate in blood plasma.
6-MeO-THH, or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH). 6-MeO-THH is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines. [1]
RCS-4 is a potent cannabinoid receptor agonist, with EC 50 values of 146 nM for human CB 1 receptors, and 46 nM for human CB 2 receptors. [2] All methoxyphenyl regioisomers, and N -butyl homologues of RCS-4 and its regioisomers also display potent agonist activities at CB 1 and CB 2 receptors.
The Nenitzescu indole synthesis. This reaction was named for its discoverer, Costin Nenițescu, who first reported it in 1929. [1] It can be performed with a number of different combinations of R-groups, which include methyl, methoxy, ethyl, propyl, and H substituents. [2]
Camptothecin (CPT) is a topoisomerase inhibitor.It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs.It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine.