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Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold [ 4 ] and may also be used for sedating people who are agitated or anxious, an effect that has led to ...
In 2022, the deaths of 66 children in The Gambia were linked to four pediatric cough syrup medications that contained diethylene glycol and ethylene glycol. [ 44 ] [ 45 ] In 2022, the US Food and Drug Administration issued a warning against cooking foods in cough syrup after a video of someone preparing "NyQuil chicken", sometimes also called ...
In July 1975, the J. B. Williams Co. began marketing Sominex 2. [37] On November 24, 1975, Attorney General Evelle J. Younger filed suit on behalf of the State of California against Williams Co., stating that the product did not warn against use by pregnant or nursing women or persons with asthma or COPD, nor did it notify consumers that it should not be used in conjunction with alcohol. [38]
In 1947, it synthesized promethazine, a phenothiazine derivative, which was found to have more pronounced sedative and antihistaminic effects than earlier drugs. [ 59 ] : 77 A year later, the French surgeon Pierre Huguenard used promethazine together with pethidine as part of a cocktail to induce relaxation and indifference in surgical patients.
The time to reach maximum concentration (T max) of hydroxyzine is about 2.0 hours in both adults and children and its elimination half-life is around 20.0 hours in adults (mean age 29.3 years) and 7.1 hours in children. [5] [6] Its elimination half-life is shorter in children compared to adults. [5]
A teen actor, whose credits include the 2017 film Baby Driver and the reboot of the television action series MacGyver, died after he reportedly fell from a moving vehicle in Alabama last week ...
Diphenhydramine (Benadryl) was synthesized in 1943, tripelennamine (Pyribenzamine) was patented in 1946, and promethazine (Phenergan) was synthesized in 1947 and launched in 1949. [ 22 ] [ 23 ] [ 24 ] By 1950, at least 20 antihistamines had been marketed. [ 25 ]
The American Dental Association says the decades-old intervention reduces tooth decay by more than 25% in adults and children. "President Trump is giving him two years to show success," Bigtree said.
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