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[19] [31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. [19] Because there is a growing number of medications that are known to interact with citrus, [ 1 ] patients should consult a pharmacist or physician before ...
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
This prevents oxidative metabolism of certain drugs by the enzyme, resulting in an elevated concentration of drug in the bloodstream. Under normal circumstances, the grapefruit juice effect is considered to be a negative interaction, and patients are often warned not to consume grapefruit or its juice when taking medication.
For example, when the blood pressure drug felodipine is taken with grapefruit juice rather than water, levels of the medication in the blood can more than double and result in headache, irregular ...
The Health Benefits Of Grapefruit. Water-rich grapefruit contains a variety of nutrients that your body needs. One cup of grapefruit contains over 100% of your daily vitamin C, in addition to ...
Each affected drug has either a specific increase of effect or decrease. [24] One whole grapefruit or a glass of 200 ml (7 US fl oz) of grapefruit juice is enough to cause drug overdose toxicity. [21] Typically, drugs that are incompatible with grapefruit are marked as such on the container or package insert. [21]
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