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The absolute bioavailability is the dose-corrected area under curve (AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered).
Absolute bioavailability refers to the bioavailability of a drug when administered via an extravascular dosage form (i.e. oral tablet, suppository, subcutaneous, etc.) compared with the bioavailability of the same drug administered intravenously (IV). This is done by comparing the AUC of the non-intravenous dosage form with the AUC for the drug ...
The bioavailability of those products is limited by their solvation rate. A correlation between the in vivo bioavailability and the in vitro solvation can be found. Class III – low permeability, high solubility . Example: cimetidine; The absorption is limited by the permeation rate but the drug is solvated very fast.
Drug class: Psychostimulant; ... Formula: C 10 H 15 N: Molar mass: 149.237 g·mol −1: ... The oral bioavailability of phentermine is not affected by intake of a ...
Subcutaneous bioavailability has never been measured but is presumed to be high. [133] Among the less invasive routes, the intranasal route has the highest bioavailability (45–50%) [7] [10] and oral – the lowest (16–20%). [7] [10] Sublingual and rectal bioavailabilities are intermediate at approximately 25–50%. [7] [11] [10]
The oral bioavailability of gabapentin is approximately 80% at 100 mg administered three times daily once every 8 hours, but decreases to 60% at 300 mg, 47% at 400 mg, 34% at 800 mg, 33% at 1,200 mg, and 27% at 1,600 mg, all with the same dosing schedule.
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Drug class: Typical antipsychotic: ATC code: N05AA01 ... Formula: C 17 H 19 Cl N 2 S: Molar mass: ... Bioavailability t max C SS Protein bound V d