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Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
Whooping cough (/ ˈ h uː p ɪ ŋ / or / ˈ w uː p ɪ ŋ /), also known as pertussis or the 100-day cough, is a highly contagious, vaccine-preventable bacterial disease. [1] [10] Initial symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough, but these are followed by two or three months of severe coughing fits. [1]
Bordetella sp. is typically found to live within the hosts' respiratory tract and immune system and can transmit to new hosts. [5] Bordetella pertussis also affects human adults and even with an 85% vaccination coverage over 160,000 related deaths occur each year all around the globe. [ 5 ]
Whooping cough bacteria Bordetella pertussis in human airways; nurse prepares syringe with vaccine against whooping cough; Migrants from the southern border being dropped of at Trenton ...
A sentinel surveillance system is used to obtain data about a particular disease that cannot be obtained through a passive system such as summarizing standard public health reports. Data collected in a well-designed sentinel system can be used to signal trends, identify outbreaks and monitor disease burden, providing a rapid, economical ...
Aug. 22—GRANT COUNTY — The Grant County Health District is responding to a concerning spike in whooping cough, also known as pertussis, cases, with 28 infections confirmed since June ...
Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein.The protein consists of three domains: from the N-terminus up to roughly residue 400, there is an adenylate-cyclase domain; between residues 500 and 700, there is a hydrophobic domain; and from residue 1000 to the C-terminus, there are calcium binding repeats.
Pertussis vaccine is a vaccine that protects against whooping cough (pertussis). [ 1 ] [ 2 ] There are two main types: whole-cell vaccines and acellular vaccines. [ 1 ] [ 2 ] The whole-cell vaccine is about 78% effective while the acellular vaccine is 71–85% effective.