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Although the largest numbers of these are human and mouse cell lines, records are also available for rat, bonobo, dog, squirrel, pig, green monkey and naked mole-rat. Ontologies: In order to make RGD's data both human readable and available for computational analysis and retrieval, RGD relies on the use of multiple ontologies. As of July 2021 ...
In studies where the interscapular brown adipose tissue of rats were lesioned, it was demonstrated that the rats had difficulty regulating their normal body-weight. [ 61 ] The longest-lived small mammals, bats (30 years) and naked mole rats (32 years), all have remarkably high levels of brown adipose tissue and brown adipose tissue activity.
However, unlike vertebrates, lobsters express telomerase as adults through most tissue, which has been suggested to be related to their longevity. [24] [25] [26] Contrary to popular belief, lobsters are not immortal. Lobsters grow by moulting, which requires considerable energy, and the larger the shell the more energy is required. [27]
The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
[19] [20] For example, the sponge-dwelling shrimp depend upon the sponge's feeding current for food, termites depend upon dead, decaying wood, and naked mole rats depend upon tubers in the ground. [5] [13] [21] Each of these resources has patchy distributions throughout the environments of these animals. This means there is a high cost to ...
However, some mutations that increase ROS production (e.g., by reducing antioxidant defenses) in worms increase, rather than decrease, their longevity. [72] Also, naked mole rats, rodents about the size of mice, live about eight times longer than mice despite having reduced, compared to mice, antioxidant defenses and increased oxidative damage ...
They are most highly developed in the blind mole-rats, whose eyes are completely covered by skin, and entirely lack external ears or tails. All of the spalacid species dig extensive burrows, which may include storage chambers for food, latrine chambers, and breeding nests.
The maximum life spans of mice, naked mole-rats and humans are respectively ~3, ~30 and ~129 years. [69] Of these, the shortest lived species, mouse, expresses DNA repair genes, including core genes in several DNA repair pathways, at a lower level than do humans and naked mole rats. [ 69 ]