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Trazodone was the second-most prescribed agent for insomnia in the early 2000s even though most studies of trazodone for the treatment of sleep disturbances have been in depressed individuals. [ 13 ] [ 34 ] [ 35 ]
Sleep studies have been imperative for the empirical research of sleep psychology. The area of sleep psychology evaluates the physiological, and behavioral factors of normal sleep and sleep disorders along with the neuroscience and brain-wave activity associated with sleep, as well as the study of circadian rhythms. [12]
Some studies found that the abrupt substitution of substitutive pharmacotherapy was actually less effective than gradual dose reduction alone, and only three studies found benefits of adding melatonin, [74] paroxetine, [75] trazodone, [76] or valproate [76] in conjunction with a gradual dose reduction. [71]
Chemical structure of the serotonin antagonist and reuptake inhibitor trazodone.. Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics.
Polyphasic sleep is the term used to describe any sleep pattern that includes three or more periods of shuteye in a 24-hour period instead of the more traditional large snooze at night.
This is a list of adverse effects of the antidepressant trazodone, sorted by frequency of occurrence. [1] [2] [3] Very common.
Sleep studies using polysomnography have suggested that people who have sleep disruption have elevated night-time levels of circulating cortisol and adrenocorticotropic hormone. [71] They also have an elevated metabolic rate, which does not occur in people who do not have insomnia but whose sleep is intentionally disrupted during a sleep study.
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]
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