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Ovarian origin: sex-cord stromal tumor, germ cell tumor [3] Non-ovarian origin: most epithelial ovarian cancers and epithelial–stromal ovarian tumors [3] Risk factors: Never having children, hormone therapy after menopause, fertility medication, obesity, genetics [4] [5] [6] Diagnostic method: Tissue biopsy [1] Treatment
Sertoli–Leydig cell tumour (a sex-cord stromal tumor), is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group [2] of ovarian and testicular cancers. The tumour occurs in early adulthood (not seen in newborn), is rare, comprising less than 1% of testicular tumours. [ 1 ]
A prospective study of ovarian sex cord–stromal tumours in children and adolescents began enrolling participants in 2005. [14] The International Ovarian and Testicular Stromal Tumor Registry is studying these rare tumours and collecting data on them to further research. Targeted treatments are being evaluated for these tumours as well. [1]
Ovarian tumors, or ovarian neoplasms, are tumors in the ovary. [1] Not all are ovarian cancer. [1] They consist of mainly solid tissue, while ovarian cysts contain fluid. [2]In 2020, the World Health Organization (WHO) divided ovarian tumours as 90% epithelial, 3% germ cell, and 2% sex cord-stromal types.
Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium (modified peritoneum) or from ectopic endometrial or fallopian tube (tubal) tissue.
They are estrogen-secreting tumours and present as large, complex, ovarian masses. These tumours are part of the sex cord–gonadal stromal tumour or non-epithelial group of tumours. Although granulosa cells normally occur only in the ovary, granulosa cell tumours occur in both ovaries and testicles (see ovarian cancer and testicular cancer ...
Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and (testicular) interstitial cell tumor (US spelling), is a member of the sex cord-stromal tumour group [2] of ovarian and testicular cancers. It arises from Leydig cells. While the tumour can occur at any age, it occurs most often in young adults.
A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a sex cord–gonadal stromal tumour of Sertoli cells. They can occur in the testis or ovary. They are very rare and generally peak between the ages of 35 and 50. They are typically well-differentiated and may be misdiagnosed as seminomas as they often appear very similar. [1]
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