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The white matter is substantially affected, with noticeable atrophy (tissue loss), in addition to calcification of the arteries. [2] [6] [17] Microinfarcts may also be present in the gray matter (cerebral cortex), sometimes in large numbers. [2]
Reviews of neuroimaging studies indicate that consistent aerobic exercise increases gray matter volume in nearly all regions of the brain, [31] with more pronounced increases occurring in brain regions associated with memory processing, cognitive control, motor function, and reward; [1] [5] [31] the most prominent gains in gray matter volume are seen in the prefrontal cortex, caudate nucleus ...
Age-related decrease in gray matter volume was the largest contribution to changes in brain volume. Moreover, neuronal density appears to decrease, white matter microstructure gets altered and energy metabolism in the cerebellum gets altered. [16] General cortical atrophy occurs in aging and e.g. the caudate nucleus volume appears to decrease.
In 1892, Paul Blocq and Gheorghe Marinescu first described the presence of plaques in grey matter. [8] [9] They referred to the plaques as 'nodules of neuroglial sclerosis'.In 1898, Emil Redlich reported plaques in three patients, two of whom had clinically verified dementia. [10]
This allows researchers to quantify anatomical features of the brain in terms of shape, mass, volume (e.g. of the hippocampus, or of the primary versus secondary visual cortex), and to derive more specific information, such as the encephalization quotient, grey matter density and white matter connectivity, gyrification, cortical thickness, or ...
The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]
White matter is the tissue through which messages pass between different areas of grey matter within the central nervous system. The white matter is white because of the fatty substance (myelin) that surrounds the nerve fibers (axons). This myelin is found in almost all long nerve fibers, and acts as an electrical insulation.
Grey matter contains most of the brain's neuronal cell bodies. [6] The grey matter includes regions of the brain involved in muscle control, and sensory perception such as seeing and hearing, memory, emotions, speech, decision-making, and self-control. The grey matter in the spinal cord is split into three grey columns: