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Girls seem to be somewhat more commonly affected. The disease less commonly begins during puberty or after age 20, and very rarely, cases in older adults have been reported. Due to commonly being misdiagnosed, it is common for the disease to remain untreated. When left untreated, patients often need Achilles' tendon surgery by the age of 21.
This can cause ambulation impairment, such as trouble climbing stairs or maintaining balance. Gait abnormality is also common in persons with nervous system problems such as cauda equina syndrome , multiple sclerosis , Parkinson's disease (with characteristic Parkinsonian gait ), Alzheimer's disease , vitamin B 12 deficiency , myasthenia gravis ...
A number of studies implicate the combination of high cyanide intake from bitter cassava and low intake of sulfur amino acids as the cause. It has now been shown that the month by month incidence of konzo is significantly correlated with the percentage of children with high urinary thiocyanate content, which is a measure of their cyanide intake.
Gait deviations are nominally referred to as any variation of standard human gait, typically manifesting as a coping mechanism in response to an anatomical impairment. Lower-limb amputees are unable to maintain the characteristic walking patterns of an able-bodied individual due to the removal of some portion of the impaired leg.
VT causes syncope and can result in sudden death. [20] Ventricular tachycardia, which describes a heart rate of over 100 beats per minute with at least three irregular heartbeats as a sequence of consecutive premature beats, can degenerate into ventricular fibrillation , which is rapidly fatal without cardiopulmonary resuscitation (CPR) and ...
A limp is a type of asymmetric abnormality of the gait.Limping may be caused by pain, weakness, neuromuscular imbalance, or a skeletal deformity. The most common underlying cause of a painful limp is physical trauma; however, in the absence of trauma, other serious causes, such as septic arthritis or slipped capital femoral epiphysis, may be present.
The exact pathophysiological causes of the disease are currently unclear, but there are developing theories. [8] Spongy degeneration can be diagnosed with neuroimaging techniques and urine examination. [9] There is no current treatment for spongy degeneration, but research utilising gene therapy to treat the disease is underway. [8]
Failure in diagnosis of WE and thus treatment of the disease leads to death in approximately 20% of cases, while 75% are left with permanent brain damage associated with WKS. [4] Of those affected, 25% require long-term institutionalization in order to receive effective care.