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Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1 , a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis .
In the diagram, the adrenal gland (1) releases androstenedione (3) while the ovaries (2) secrete testosterone (4). Both hormones travel to peripheral tissues or a breast cell (5), where they would be converted into estrone (8) or estradiol (9) if not for AIs (7), which prevent the enzyme CYP19A1 (also known as aromatase or estrogen synthase) (6 ...
What do unbalanced levels of testosterone look like? Low testosterone can negatively impact sexual function, mood, energy level, muscle mass, and weight, according to Javaid. ... too. “Before ...
17β-Hydroxysteroid dehydrogenase (17β-HSD) inhibitors prevent the reversible conversion of the weak androgens dehydroepiandrosterone (DHEA) and 4-androstenedione into the more potent androgen testosterone and the weak estrogen estrone into the more potent estrogen estradiol. [27]
The idea that testosterone could be the missing piece of the hormone therapy (HRT) jigsaw puzzle, alongside the female sex hormones estrogen and progesterone, was first sparked by a change in the ...
Testosterone is an essential hormone for both men and women, playing an important role in muscle growth and cognitive function. Low levels of the hormone can lead to changes in mood, cognition and ...
17β-Hydroxysteroid dehydrogenase inhibitors (17β-HSD inhibitors): inhibit the interconversion of androgens, including the synthesis of testosterone from the less-potent androstenedione; 5α-Reductase inhibitors (5α-RIs; SRD5A inhibitors): inhibit the conversion of testosterone into the more potent DHT
[21] [22] [23] Treatment of men with medical castration and add-back testosterone to restore testosterone levels, with or without the aromatase inhibitor anastrozole, showed that prevention of the conversion of testosterone into estradiol partially prevented restoration of sexual desire and erectile dysfunction by testosterone in men. [32]
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