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A BLAST variant called MegaBLAST indexes 4 databases to speed up alignments. [9] BLAT can extend on multiple perfect and near-perfect matches (default is 2 perfect matches of length 11 for nucleotide searches and 3 perfect matches of length 4 for protein searches), while BLAST extends only when one or two matches occur close together. [1] [9]
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It makes use of the BLAST [5] algorithm to identify similar sequences to then transfers existing functional annotation from yet characterised sequences to the novel one. The functional information is represented via the Gene Ontology (GO), a controlled vocabulary of functional attributes.
While BLAST does a linear search, BLAT relies on k-mer indexing the database, and can thus often find seeds faster. [23] Another software alternative similar to BLAT is PatternHunter . Advances in sequencing technology in the late 2000s has made searching for very similar nucleotide matches an important problem.
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The game was released in 2017 commercially on Steam by independent developer Undertow Games (Joonas "Regalis" Rikkonen). Source code was released on 4 June 2017 on GitHub under a restrictive mods allowing license. [5] [6] His previous game, SCP – Containment Breach, is also available as free and open-source software under CC BY-SA license.