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2. Mirtazapine - Wikipedia

   en.wikipedia.org/wiki/Mirtazapine

   Mirtazapine is a very strong H 1 receptor antagonist and, as a result, it can cause powerful sedative and hypnotic effects. [11] A single 15 mg dose of mirtazapine to healthy volunteers has been found to result in over 80% occupancy of the H 1 receptor and to induce intense sleepiness. [92]

3. Noradrenergic and specific serotonergic antidepressant

   en.wikipedia.org/wiki/Noradrenergic_and_specific...

   Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]

4. Doctors Say These 12 Home Remedies for Constipation Actually Work

   www.aol.com/doctors-12-home-remedies...

   7. Move more. You may notice that if you take a break from your exercise routine, you get more backed up. “A more sedentary state leads to more constipation,” says Dr. Mathur, who adds that ...

5. Alpha-2 blocker - Wikipedia

   en.wikipedia.org/wiki/Alpha-2_blocker

   The tetracyclic antidepressants mianserin and mirtazapine are α 2 blockers, although their efficacy as antidepressants may come from their activity at other receptor sites. [citation needed] Mechanistically, α 2 blockers increase adrenergic, dopaminergic and serotonergic neurotransmitters and induce insulin secretion, decreasing blood sugar ...

6. Serotonin receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/Serotonin_receptor_antagonist

   Although some non-selective serotonin antagonists may have a particular affinity for a specific 5-HT receptor (and thus may be listed below e.g., methysergide), they still may also possess a generalised non-selective action.

7. 5-HT3 antagonist - Wikipedia

   en.wikipedia.org/wiki/5-HT3_antagonist

   0.25 mg dose Ramosetron: Benzimidazole derivative 5-HT 3 receptor antagonist 5.8 hours 300 μg/kg Tropisetron [30] Indole: 5-HT 3 receptor antagonist 5.6 hours CYP 3A3/4/5, CYP2D6: 200 μg/kg Vortioxetine: Phenylpiperazine: 5-HT 3 receptor antagonist Antidepressant 66h CYP 2D6/ 2A6/CYP2B6/CYP2C8/9, CYP2C19: 5 mg, 10 mg, 20 mg doses

8. Doctors Say This Viral "Sleep Rule" Actually Works - AOL

   www.aol.com/doctors-viral-sleep-rule-actually...

   The amount of caffeine can have an impact, too, so at most, try to limit caffeine to 200 to 400 mg per day (be mindful that a single cup can contain anywhere from 200 to 400 mg, depending on the ...

9. Serotonin–norepinephrine reuptake inhibitor - Wikipedia

   en.wikipedia.org/wiki/Serotonin–norepinephrine...

   The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. It is related in chemical structure to venlafaxine. Due to being an opioid, there is risk of abuse and addiction, but it does have less abuse potential, respiratory depression, and constipation compared to other opioids (hydrocodone, oxycodone ...