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The microtubule-organizing center (MTOC) is a structure found in eukaryotic cells from which microtubules emerge. MTOCs have two main functions: the organization of eukaryotic flagella and cilia and the organization of the mitotic and meiotic spindle apparatus, which separate the chromosomes during cell division.
Nucleation is the event that initiates the formation of microtubules from the tubulin dimer. Microtubules are typically nucleated and organized by organelles called microtubule-organizing centers (MTOCs). Contained within the MTOC is another type of tubulin, γ-tubulin, which is distinct from the α- and β-subunits of the microtubules themselves.
In cell biology, the centrosome (Latin centrum 'center' + Greek sōma 'body') (archaically cytocentre [1]) is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell, as well as a regulator of cell-cycle progression. The centrosome provides structure for the cell.
Also, the dynein arms attached to the microtubules function as the molecular motors. The motion of the cilia and flagella is created by the microtubules sliding past one another, which requires ATP. [31] They play key roles in: intracellular transport (associated with dyneins and kinesins, they transport organelles like mitochondria or vesicles).
Since the centrosome organizes the microtubules of a cell, it has to do with the formation of the mitotic spindle, polarity and, therefore, cell shape, as well as all other processes having to do with the mitotic spindle. [2] The centriole is the inner core of the centrosome, and its conformation is typically somewhat like that of spokes on a ...
In cell biology, an organelle is a specialized subunit, usually within a cell, that has a specific function. The name organelle comes from the idea that these structures are parts of cells, as organs are to the body , hence organelle, the suffix -elle being a diminutive .
Micrograph showing condensed chromosomes in blue, kinetochores in pink, and microtubules in green during metaphase of mitosis. In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.
Microtubules are organized so their plus ends extend through the periphery of the cells and their minus ends are anchored within the centrosome, so they utilize the motor proteins kinesin’s (positive end directed) and dynein’s (negative end directed) to transport vesicles and organelles in opposite directions through the cytoplasm. [6]