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  2. Cyclin-dependent kinase inhibitor protein - Wikipedia

    en.wikipedia.org/wiki/Cyclin-dependent_kinase...

    In the cyclin-dependent kinase (CDK) family, or CDK, Cyclin, and CKIs, serine/threonine kinases play an integral role in regulating the eukaryotic cell cycle. The structure of CDK2-CyclinA and p27 is determined by crystallography, demonstrating that the inhibitor of p27 stretches at the top of the Cyclin-CDK complex. The amino terminal of p27 ...

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  4. CDK-activating kinase - Wikipedia

    en.wikipedia.org/wiki/CDK-activating_kinase

    CDK-activating kinase (CAK) activates the cyclin-CDK complex by phosphorylating threonine residue 160 in the CDK activation loop. CAK itself is a member of the Cdk family and functions as a positive regulator of Cdk1 , Cdk2 , Cdk4 , and Cdk6 .

  5. In the race for holiday shoppers' dollars, Amazon is setting ...

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    Target, for example, has narrowed the online price gap with Amazon in key product categories since last year, Profitero found. ... An outerwear upgrade: Shop this on-sale knit jacket for just $34 ...

  6. Tracing the powerful family roots of suspected killer Luigi ...

    www.aol.com/tracing-powerful-family-roots...

    The name is literally imprinted on Baltimore. A plaque at the entrance to the Family Center at the Greater Baltimore Medical Center reads: "Donated by Nicholas and Mary Mangione."

  7. The world’s busiest flight routes for 2024 revealed - AOL

    www.aol.com/news/world-busiest-flight-routes...

    Editor’s note: Sign up for Unlocking the World, CNN Travel’s weekly newsletter. Get news about destinations, plus the latest in aviation, food and drink, and where to stay. If you think planes ...

  8. If you want to help your kids bypass probate when you die ...

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    No need to put this in a revocable trust. Simply name your beneficiaries within the policy. Or, create an irrevocable life insurance trust (ILIT) to avoid estate taxes.

  9. “The idea is that pedestrians are the No. 1 mode of transportation” along the strip, she said. “They have to be a priority. … It’s very clear that we need to address that.” ...