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It is also found in pancreatic beta cells, vascular endothelium, and macrophages [45] Rosiglitazone is a selective ligand of PPARγ and has no PPARα-binding action. Other drugs bind to PPARα. Rosiglitazone also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance.
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases ...
G.I. Joe: Cobra Strike is an action video game written by John Emerson for the Atari 2600 and published in 1983 by Parker Brothers. [2] The game is loosely based on the G.I. Joe franchise and is the first licensed G.I. Joe video game. [3] There are three game modes: single-player, two player cooperative, and two player competitive.
Action Force: International Heroes is a video game released by Virgin Games in 1987 for the ZX Spectrum and Commodore 64, and in 1988 for the Amstrad CPC. The game is set in the world of the Action Force ( G.I. Joe ) toys by Hasbro .
How 2 men transformed an Annapolis radio station for Black listeners in the 60s. News. News. USA TODAY 'Critical moment in history': Protests across US target Trump, Musk. News. CBS News.
The Webster Police Department worked with the Galveston County Auto Crimes Task Force, League City Police Department and Seabrook Police Department to apprehend the suspects. Ford F-350s have been ...
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes.