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In the season 10 Big Bang Theory Comic-Con special, Steve Molaro told a story about how he first met actor Judd Hirsch and was taken aback by his dilated pupil. One of the other writers researched it and discovered that Judd Hirsch has anisocoria. American actress Melissa Benoist developed this condition in 2015.
A way to demonstrate aniseikonia is to hold a near target (e.g., a pen or a finger) approximately 6 inches directly in front of one eye. The person then closes one eye, and then the other. The person should notice that the target appears larger to the eye that it is directly in front of.
Tonic pupils are fairly common – they are seen in roughly 1 out of every 500 people. A person with anisocoria (one pupil bigger than the other) whose pupil does not react to light (does not constrict when exposed to bright light) most likely has Adie syndrome – idiopathic degeneration of the ciliary ganglion.
Polycoria is a pathological condition of the eye characterized by more than one pupillary opening in the iris. [1] It may be congenital or result from a disease affecting the iris. [ 1 ] It results in decreased function of the iris and pupil, affecting the physical eye and visualization.
The main characteristic that distinguishes physiological anisocoria is an increase of pupil size with lower light or reduced illumination, such that the pupils differ in size between the two eyes. At any given eye examination, up to 41% of healthy patients can show an anisocoria of 0.4 mm or more at one time or another.
The pupil diameter can vary greatly due to various factors (primarily the pupillary light reflex), from constriction to as small as 2 mm, to dilation larger than 8 mm in some individuals, though the maximal dilation also varies substantially by individual and decreases with age. The pupil gets wider in the dark and narrower in light.
Hypertropia is a condition of misalignment of the eyes (), whereby the visual axis of one eye is higher than the fellow fixating eye. Hypotropia is the similar condition, focus being on the eye with the visual axis lower than the fellow fixating eye.
A hypercentric or pericentric lens is a lens system where the entrance pupil is located in front of the lens, in the space where an object could be located. In a certain region, objects that are further away from the lens produce larger images than objects that are closer to the lens.