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In a Mayo Clinic study, for example, AL amyloidosis assigned stage 1, 2, 3, or 4 based on the presence of 0, 1, 2, or 3 prognostic signs (high blood levels of [cardiac troponin T]), blood levels of a marker for congestive heart failure (viz., NT-ProBNP), or free light chain ratios) had median survivals of 94.1, 40.3, 14, and 5.8 months ...
Guanidinoacetate methyltransferase deficiency (GAMT deficiency) is an autosomal recessive [1] cerebral creatine deficiency that primarily affects the nervous system and muscles. It is the first described disorder of creatine metabolism, [ 2 ] and results from deficient activity of guanidinoacetate methyltransferase , an enzyme involved in the ...
In molecular biology, enzymes in the DNA/RNA non-specific endonuclease family of bacterial and eukaryotic endonucleases EC 3.1.30.-share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity.
The restriction endonuclease Fok1, naturally found in Flavobacterium okeanokoites, is a bacterial type IIS restriction endonuclease consisting of an N-terminal DNA-binding domain and a non sequence-specific DNA cleavage domain at the C-terminal. [2]
The non-specific DNA cleavage domain from the end of the FokI endonuclease can be used to construct hybrid nucleases that are active in a yeast assay. [ 6 ] [ 7 ] These reagents are also active in plant cells [ 8 ] [ 9 ] and in animal cells.
Ribonuclease H (abbreviated RNase H or RNH) is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic mechanism. Members of the RNase H family can be found in nearly all organisms, from bacteria to archaea to eukaryotes.
13804 Ensembl ENSG00000167136 ENSMUSG00000015337 UniProt Q14249 O08600 RefSeq (mRNA) NM_004435 NM_007931 RefSeq (protein) NP_004426 NP_031957 Location (UCSC) Chr 9: 128.82 – 128.82 Mb Chr 2: 30.06 – 30.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. This protein primarily participates in ...
Proteinuria (protein in the urine) ranging from sub-nephrotic (<3.5 g/day) to >10 g/day, [7] although it is rarely above nephrotic range proteinuria levels. [12] Hypertension [13] resting blood pressure is persistently at or above 130/80 or 140/90 mmHg. [14] Blurred vision [4] Azotemia (increased plasma Urea and Creatinine) [2] Oliguria (low ...