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Aprotinin is a monomeric (single-chain) globular polypeptide derived from bovine lung tissue. It has a molecular weight of 6512 Da and consists of 16 different amino acid types arranged in a chain 58 residues long [4] [5] that folds into a stable, compact tertiary structure of the 'small SS-rich" type, containing 3 disulfides, a twisted β-hairpin and a C-terminal α-helix.
They are relatively small with a length of about 50 to 60 amino acids and a molecular weight of 6 kDa. Examples of Kunitz-type protease inhibitors are aprotinin (bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI).
Molecular weight Inhibitory power Details Blood plasma: α 1-antitrypsin: 52 kDa: Also known as serum trypsin inhibitor Lima beans: 8–10 kDa 2.2 times weight A mixture of six different inhibitors Bovine pancreas and lung: Aprotinin: 6.5 kDa 2.5 times weight Also known as BPTI (basic pancreatic trypsin inhibitor) and Kunitz inhibitor.
These were developed in 2010 to replace the use of aprotinin during and after cardiac surgery, including surgeries with cardiopulmonary bypass which cause blood loss and hemorrhagic complications. [2] CU-2010 and CU-2020 were developed to avoid many issues associated with the use of aprotinin, including the risk of an allergic reaction and ...
Leupeptin, also known as N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases.. It is often used during in vitro experiments when a specific enzymatic reaction is being studied.
ATC code B Blood and blood forming organs is a section of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
4035 16971 Ensembl ENSG00000123384 ENSMUSG00000040249 UniProt Q07954 Q91ZX7 RefSeq (mRNA) NM_002332 NM_008512 RefSeq (protein) NP_002323 NP_032538 Location (UCSC) Chr 12: 57.13 – 57.21 Mb Chr 10: 127.37 – 127.46 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR ...
A protein is a complex, high molecular weight organic compound that consists of amino acids joined by peptide bonds. Organize articles about proteins according to a standard protein ontology . Contents
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related to: aprotinin molecular weight