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WISP-1 is upregulated in human patients with idiopathic pulmonary fibrosis and in a mouse model of bleomycin-induced lung fibrosis. [30] Orotracheal application of CCN4 neutralizing antibodies to the lung ameliorates bleomycin-induced lung fibrosis, [30] raising the possibility that CCN4 might be a potential target for anti-fibrotic therapy. [5]
However, the inhibitory activity of Siglec-8 extends beyond counteracting FcεRI-mediated mast cell activation in transgenic mice: monoclonal antibody engagement of Siglec-8 reduced mast cell activation, immune cell recruitment, and lung fibrosis in a cigarette smoke-induced model of chronic obstructive pulmonary disease and in a bleomycin ...
The most serious complication of bleomycin, occurring upon increasing dosage, is pulmonary fibrosis and impaired lung function. It has been suggested that bleomycin induces sensitivity to oxygen toxicity [14] and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury ...
14219 Ensembl ENSG00000118523 ENSMUSG00000019997 UniProt P29279 P29268 RefSeq (mRNA) NM_001901 NM_010217 RefSeq (protein) NP_001892 NP_034347 Location (UCSC) Chr 6: 131.95 – 131.95 Mb Chr 10: 24.47 – 24.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular ...
In this model, bleomycin administration results in oxidative stress and acute inflammation, with the subsequent onset of pulmonary fibrosis in a number of animal species including the mouse and hamster. [15] [30] Numerous studies have demonstrated that pirfenidone attenuates bleomycin-induced pulmonary fibrosis.
Role of Thy-1 in fibrosis and fibroblast differentiation may have some tissue variation. Thy1 knock out mice have increased fibrosis in the lung. Fibrosis induced by chemotherapeutic agent Bleomycin is also increased in these mice.
Pulmonary fibrosis is a condition in which the lungs become scarred over time. [1] Symptoms include shortness of breath , a dry cough, feeling tired, weight loss, and nail clubbing . [ 1 ] Complications may include pulmonary hypertension , respiratory failure , pneumothorax , and lung cancer .
[9] [11] On the other hand, IP receptors may serve to promote non-allergic inflammatory responses: IP receptor-deficient mice exhibited increased lung inflammation in a model of bleomycin-induced pulmonary fibrosis while mice made to over-express the PGI 2-forming enzyme, Prostacyclin synthase, in their airway epithelial cells were protected ...
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