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In the pursuit of understanding and developing treatments for asthma, researchers have explored various models, including animal models like mice and rats, to mimic different aspects of the condition. While these animal models have contributed to our knowledge, they come with limitations, particularly in terms of translatability to humans. [14]
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease where the lining of the lungs become thickened and scarred. [15] Increased ROCK activity has been found in the lungs of humans and animals with IPF. Treatment with belumosudil reduced lung fibrosis in a bleomycin mouse model study. [16]
Adropin showed antifibrotic activity in mouse models of skin and lung fibrosis as well as in human skin biopsies. Thus, adropin is a potential therapeutic target in tissue fibrosis. [ 36 ]
However, he soon found that there were major limitation of mouse models to study CF. He later found that the ferrets represent a much better model for lung disease and in 2006 his laboratory became the first in the world to clone ferrets. [4] Dr. Engelhardt's research has been geared towards finding gene therapies for cystic fibrosis.
WISP-1 is upregulated in human patients with idiopathic pulmonary fibrosis and in a mouse model of bleomycin-induced lung fibrosis. [30] Orotracheal application of CCN4 neutralizing antibodies to the lung ameliorates bleomycin-induced lung fibrosis, [30] raising the possibility that CCN4 might be a potential target for anti-fibrotic therapy. [5]
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans ...
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Pulmonary fibrosis is a condition in which the lungs become scarred over time. [1] Symptoms include shortness of breath , a dry cough, feeling tired, weight loss, and nail clubbing . [ 1 ] Complications may include pulmonary hypertension , respiratory failure , pneumothorax , and lung cancer .
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