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Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. [5] It is suggested to be used together with diet changes, exercise, and weight loss. [ 5 ]
The Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, commonly called the Beers List, [1] are guidelines published by the American Geriatrics Society (AGS) for healthcare professionals to help improve the safety of prescribing medications for adults 65 years and older in all except palliative settings.
Upon analysis, scientists found that participants who stayed on standard statin treatment for their lifetime increased their quality-adjusted life years by 0.24-0.70, and those on higher-intensity ...
Cholesterol synthesis appears to occur mostly at night, [140] so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, [141] [142] but have shown no difference in the long-acting ...
Another thing to avoid, according to the study, was eating too late at night. Eating at 9 p.m. was associated with a 28% increase in the risk of cerebrovascular disease, such as stroke.
It reduces total blood cholesterol by blocking the action of 3-hydroxy-3-methyl-glutaryl-coenzyme-A (HMG-CoA) reductase, an enzyme in the liver involved in the production of cholesterol. [2] As the liver needs cholesterol to produce bile, the reduced blood cholesterol level causes the liver cells to produce receptors that draw cholesterol from ...
In 2023, more than five million Americans 12 and older reported a "prescription use disorder" within the past year, according to the Centers for Disease Control and Prevention (CDC).
The ideal statin should have the following properties: [6] High affinity for the enzyme active site; Marked selectivity of uptake into hepatic cells compared with non-hepatic cells; Low systemic availability of active inhibitory equivalents; Relatively prolonged duration of effect.