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Within 24 hours of implantation, in vitro testing has shown that the calcium and phosphorus ions released from the Bioglass precipitate back onto the particles as a calcium phosphate surface layer. 3 This layer is similar to normal bone mineral, creating a surface that is more favorable to osteoblast attachment than other synthetic materials. 8 ...
Initially, focusing on bone growth, subcutaneous pockets were used for bone prefabrication as a simple in vivo bioreactor model. The pocket is an artificially created space between varying levels of subcutaneous fascia. The location provides regenerative ques to the bioreactor implant but does not rely on pre-existing bone tissue as a substrate.
Osseointegration is also defined as: "the formation of a direct interface between an implant and bone, without intervening soft tissue". [1]An osseointegrated implant is a type of implant defined as "an endosteal implant containing pores into which osteoblasts and supporting connective tissue can migrate". [2]
Orthofix Concludes Bone Growth Stimulator Investigation LEWISVILLE, Texas--(BUSINESS WIRE)-- Orthofix International N.V., (NAS: OFIX) (the Company) announced today that it has resolved all matters ...
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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
Bone ingrowth is a favorable effect, as it anchors the cells into the implant, increasing the strength of the bone-implant interface. [30] More load is transferred from the implant to the bone, reducing stress shielding effects. The density of the bone around the implant is likely to be higher due to the increased load applied to the bone.
An artificial organ is a human-made organ device or tissue that is implanted or integrated into a human – interfacing with living tissue – to replace a natural organ, to duplicate or augment a specific function or functions so the patient may return to a normal life as soon as possible. [1]
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