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If these conditions persist, a chronic inflammatory response may set in, resulting in extensive tissue destruction. 2 With respect to implant materials, chronic inflammation and foreign body reactions are associated with the development of a fibrous capsule around the implant. The goal of a graft material is to aid in tissue healing.
Osseointegration is also defined as: "the formation of a direct interface between an implant and bone, without intervening soft tissue". [1]An osseointegrated implant is a type of implant defined as "an endosteal implant containing pores into which osteoblasts and supporting connective tissue can migrate". [2]
Artificial bone refers to bone-like material created in a laboratory that can be used in bone grafts, to replace human bone that was lost due to severe fractures, disease, etc. [1] Bone fracture, which is a complete or partial break in the bone, is a very common condition that has more than three million US cases per year. [ 2 ]
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
A bone growth factor is a growth factor that stimulates the growth of bone tissue. [1] [2]Known bone growth factors include insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid hormone-related peptide (PTHrP), bone morphogenetic proteins (BMPs ...
Osseoincorporation is the healing potential of bone onto an implant surface and into an implant structure. Three-dimensional, porous implantable materials used in the orthopedic and dental implant industries offer the potential for ingrowth as well as ongrowth [1] [2] [3] or osseoincorporation.
1440 12985 Ensembl ENSG00000108342 ENSMUSG00000038067 UniProt P09919 P09920 RefSeq (mRNA) NM_000759 NM_001178147 NM_172219 NM_172220 NM_009971 RefSeq (protein) NP_000750 NP_001171618 NP_757373 NP_757374 NP_034101 Location (UCSC) Chr 17: 40.02 – 40.02 Mb Chr 11: 98.59 – 98.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Granulocyte colony-stimulating factor (G-CSF or GCSF ...
The GBR principle was first examined by Dahlin et al. in 1988 on rats. The selective ingrowth of bone-forming cells into a bone defect region could be improved if the adjacent tissue is kept away with a membrane; this was confirmed in a study by Kostopoulos and Karring in 1994. GBR can be used for bone regeneration on exposed implant coils . [4]
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