Search results
Results from the WOW.Com Content Network
Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, and cellular aspects of the aging process, as well as the links between aging and age-related disease.
Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, and cellular aspects of the aging process, as well as the links between aging and age-related disease.
Hematopoietic progenitor cell liabilities and alarmins S100A8/A9-related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults. Frailty affects physical, cognitive, and social domains exposing older adults to adverse health outcomes.
Creative solutions are needed to combat increasing rates of metabolic disease and promote healthy aging. This review summarizes the latest research on protein and branched-chain amino acid restriction as interventions to alter metabolism to extend lifespan and reduce frailty in model organisms and humans.
In our investigation, we show that the targeted mutation of the transcription factor Spi1 in myeloid cells, causes a selective reduction in the activation of intramuscular macrophages to an M2-biased phenotype and that leads to reductions in sarcopenia and fibrosis during muscle aging.
Aging is concomitant with a slew of molecular changes, including significant shifts in the epigenome. These age-related alterations can be used to construct aging clocks, which are computational models thought to predict biological age.
Using text-mining, gene set enrichment and network analysis, we found that five aging hallmarks (deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication) were associated with co-occurrence of age-related diseases.
The complex relationship between aging, cellular senescence, and gut microbiome alterations has been increasingly recognized as a pivotal factor contributing to systemic inflammation and physiological decline with aging (Diwan & Sharma, 2022; Kawamoto & Hara, 2024; Sharma, 2022).
Among recently identified phenotypic biomarkers of longevity is the biogenic polyamine spermidine. Spermidine is present in all eukaryotic cells and, like other polyamines, is essential for cell growth and proliferation (Larqué et al., 2007; Pegg, 2016).
We screened 59,316 healthy individuals throughout baseline and follow-up, developed the BA model with physical measures, biochemical assays, cognitive functions, and genomics data, and then calculated the age gap, the deviation of BA from chronological age (CA).