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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
The Advanced Drug Delivery Reviews article reporting his "rule of five" is one of the most cited publications in the journal's history. [ 1 ] [ 4 ] In 2006, he received an honorary law degree from the University of Dundee and he has won various awards, including being the Society for Biomolecular Sciences ' winner of the 2006 SBS Achievement ...
[citation needed] The great majority of drugs on the market have molecular weights between 200 and 600 daltons, and particularly <500; [3] [4] they belong to the group of small molecules. A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five , which covers the numbers of hydrophilic groups, molecular ...
The Supercomputing Facility for Bioinformatics and Computational Biology, (SCFBio), IIT Delhi, was established in July 2002 with funding from Department of Biotechnology under the guidance of Prof. B. Jayaram. It aims at developing novel scientific methods and new software for genome analysis, protein structure prediction, and in silico drug ...
This is also evident in Table I, where he lists Glycine as having 3 H-bond donors, which fits with the three H's (either NH2 + COOH, or NH3+ + COO-). Famotidine is another example with 8 donors in Lipinski's table. Mhc 13:45, 14 May 2014 (UTC) Thanks for your note. Yes, your analysis does appear to be correct.
The definitions of hydrogen bond donors and acceptors used to apply Lipinski's Rule of Five [6] are easily coded in SMARTS. Donors are defined as nitrogen or oxygen atoms that have at least one directly bonded hydrogen atom: [N,n,O;!H0] or [#7,#8;!H0] (aromatic oxygen cannot have a bonded hydrogen) Acceptors are defined as nitrogen or oxygen:
Olympic figure skater Tara Lipinski says she became aware of her body 'at a young age': 'My body was my tool for my career' Kerry Justich April 13, 2023 at 11:05 AM
In analogy to the rule of five, it has been proposed that ideal fragments should follow the 'rule of three' (molecular weight < 300, ClogP < 3, the number of hydrogen bond donors and acceptors each should be < 3 and the number of rotatable bonds should be < 3). [4]