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Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17] In addition to producing PCP-like mental effects, high doses may cause a false-positive result for PCP and opiates in some drug tests. [9] [18]
Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
If healthy blood pressure is no higher than 120/80, but blood pressure is not viewed as a problem until it hits at least 140/90, consider all the damage that is being done before any intervention ...
Coricidin is used to alleviate common cold symptoms such as coughs and congestion. Other versions of Coricidin are used to reduce fever or as an expectorant, while Coricidin HBP includes chlorpheniramine for people with high blood pressure. Side effects can include diarrhea and hallucination. [4]
When symptoms increase periodically during protracted withdrawal, physiological changes may be present, including dilated pupils as well as an increase in blood pressure and heart rate. [9] The change in symptoms has been proposed to be due to changes in receptor sensitivity for GABA during the process of tolerance reversal. [25]
In medicine, systolic hypertension is defined as an elevated systolic blood pressure (SBP). [1] If the systolic blood pressure is elevated (>140) with a normal (<90) diastolic blood pressure (DBP), it is called isolated systolic hypertension. [2] Eighty percent of people with systolic hypertension are over the age of 65 years old. [3] Isolated ...
The impairment of cerebral blood flow that underlies hypertensive encephalopathy is still controversial. Normally, cerebral blood flow is maintained by an autoregulation mechanism that dilates arterioles in response to blood pressure decreases and constricts arterioles in response to blood pressure increases. This autoregulation falters when ...