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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
[citation needed] The great majority of drugs on the market have molecular weights between 200 and 600 daltons, and particularly <500; [3] [4] they belong to the group of small molecules. A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five , which covers the numbers of hydrophilic groups, molecular ...
The Supercomputing Facility for Bioinformatics and Computational Biology, (SCFBio), IIT Delhi, was established in July 2002 with funding from Department of Biotechnology under the guidance of Prof. B. Jayaram. It aims at developing novel scientific methods and new software for genome analysis, protein structure prediction, and in silico drug ...
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
Created Date: 8/30/2012 4:52:52 PM
This is also evident in Table I, where he lists Glycine as having 3 H-bond donors, which fits with the three H's (either NH2 + COOH, or NH3+ + COO-). Famotidine is another example with 8 donors in Lipinski's table. Mhc 13:45, 14 May 2014 (UTC) Thanks for your note. Yes, your analysis does appear to be correct.
Johnny Weir and Tara Lipinski American Airlines flight 5342 collided with a U.S. Army Black Hawk helicopter over the Potomac River in the Washington, D.C. area on Wednesday, Jan. 29
Lipinski won the gold medal at the 1998 Nagano Games at the age of 15, the youngest winner of an Olympic winter event. Weir competed at the 2006 and 2010 Winter Olympics.