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In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [ 2 ]
Myostatin inhibitors are a class of drugs that work by blocking the effect of myostatin, which inhibits muscle growth. In animal models and limited human studies, myostatin inhibitors have increased muscle size. They are being developed to treat obesity, sarcopenia, muscular dystrophy, and other illnesses.
The active-myostatin gene acts as a "governor" on muscle growth; myostatin is a protein that instructs muscles to stop growing. In effect, when inactive, as it is with Piedmontese cattle, it no longer prevents muscle development which is what allows for the hypertrophic condition sometimes referred to as "double muscling".
The Belgian Blue has a natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). [11] [8] Myostatin is a protein that inhibits muscle development. This mutation also interferes with fat deposition, resulting in very lean meat. [8] The truncated myostatin gene is unable to ...
Mutation and selection A Belgian Blue cow. The defect in the breed's myostatin gene is maintained through linebreeding and is responsible for its accelerated lean muscle growth. This Chihuahua mix and Great Dane shows the wide range of dog breed sizes created using selective breeding.
10220 14561 Ensembl ENSG00000135414 ENSMUSG00000025352 UniProt O95390 Q9Z1W4 RefSeq (mRNA) NM_005811 NM_010272 RefSeq (protein) NP_005802 NP_034402 Location (UCSC) Chr 12: 55.74 – 55.76 Mb Chr 10: 128.72 – 128.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in ...
Human karyogram. Neurogenetics studies the role of genetics in the development and function of the nervous system.It considers neural characteristics as phenotypes (i.e. manifestations, measurable or not, of the genetic make-up of an individual), and is mainly based on the observation that the nervous systems of individuals, even of those belonging to the same species, may not be identical.