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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five, which covers the numbers of hydrophilic groups, molecular weight and hydrophobicity. Since the drug is transported in aqueous media like blood and intracellular fluid, it has to be sufficiently water-soluble in the absolute sense (i.e. must have a ...
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
Created Date: 8/30/2012 4:52:52 PM
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Download as PDF; Printable version; ... Pages in category "Rules of thumb" ... Lipinski's rule of five; Looney 11 rule; M. Markovnikov's rule;
Although she was just 15 years old at the 1998 Winter Olympics, Lipinski recalls being "acutely aware" of what it would take to be the best in her sport. She also had an understanding of how her ...