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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five, which covers the numbers of hydrophilic groups, molecular weight and hydrophobicity. Since the drug is transported in aqueous media like blood and intracellular fluid, it has to be sufficiently water-soluble in the absolute sense (i.e. must have a ...
The definitions of hydrogen bond donors and acceptors used to apply Lipinski's Rule of Five [6] are easily coded in SMARTS. Donors are defined as nitrogen or oxygen atoms that have at least one directly bonded hydrogen atom: [N,n,O;!H0] or [#7,#8;!H0] (aromatic oxygen cannot have a bonded hydrogen)
Lipinski, 41, told TODAY contributing correspondent Kaylee Hartung. “Todd and I have a baby girl, Georgie Winter, that arrived into our arms by the most beautiful surrogate.”
Johnny Weir and Tara Lipinski American Airlines flight 5342 collided with a U.S. Army Black Hawk helicopter over the Potomac River in the Washington, D.C. area on Wednesday, Jan. 29
Blake Lively has allegedly requested for Justin Baldoni's lead attorney, Bryan Freedman, not to take her deposition in court. In a letter to Judge Lewis J. Liman filed Thursday, Jan. 30, in the U ...
Bill Lipinski (born 1937), Polish-American politician; Christopher A. Lipinski, originator of Lipinski's rule of five to evaluate druglikeness; Dan Lipinski (born 1966), Polish-American politician; Dariusz Lipiński (born 1955), Polish politician; Edward Lipiński (economist) (1888-1986), Polish economist; Jacek Lipiński (born 1966), Polish ...
There are no rigorous methods for determining the precise size of this space. The assumptions [3] used for estimating the number of potential pharmacologically active molecules, however, use the Lipinski rules, in particular the molecular weight limit of 500. The estimate also restricts the chemical elements used to be Carbon, Hydrogen, Oxygen ...