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Illustration depicting the layers of the heart wall including the innermost endocardium. The endocardium (pl.: endocardia) is the innermost layer of tissue that lines the chambers of the heart.
The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial-mesenchymal transition, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards the interior of the heart tube). These migrated cells form the "swellings" called the endocardial cushions seen in ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 24 February 2025. List of organ systems in the human body Part of a series of lists about Human anatomy General Features Regions Variations Movements Systems Structures Arteries Bones Eponymous Foramina Glands endocrine exocrine Lymphatic vessels Nerves Organs Systems Veins Muscles Abductors Adductors ...
This begins with the formation of two endocardial tubes which merge to form the tubular heart, also called the primitive heart tube. The heart is the first functional organ in vertebrate embryos . The tubular heart quickly differentiates into the truncus arteriosus , bulbus cordis , primitive ventricle , primitive atrium , and the sinus venosus .
Real-time MRI of the human heart The human heart is in the middle of the thorax, with its apex pointing to the left. [15] The human heart is situated in the mediastinum, at the level of thoracic vertebrae T5–T8. A double-membraned sac called the pericardium surrounds the heart and attaches to the mediastinum. [16]
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The endocardial tubes have an intimate proximity to the foregut or pharyngeal endoderm. [ 1 ] As folding of the embryo in the horizontal plane initiates in the 4th week of gestation, the endocardial tubes meet in the midline to form the primitive heart tube , which will eventually develop into the histologically definitive endocardium .
They conduct cardiac action potentials more quickly and efficiently than any of the other cells in the heart's electrical conduction system. [4] Purkinje fibers allow the heart's conduction system to create synchronized contractions of its ventricles, and are essential for maintaining healthy and consistent heart rhythm. [5]