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Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [11] One common adverse effect is an upset stomach. [11] More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. [11]
The first adverse reactions to aspirin were described in 1902 in Germany, only four years after aspirin's commercial introduction. [53] The first published report of an aspirin-induced asthma attack was in 1911. [54] Initial reports on the linkage between asthma, aspirin, and nasal polyposis were made by Georges-Fernand Widal et al. in 1922. [55]
Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. [1] Early on, these may be subtle, while larger doses may result in fever.
As there are potentially serious side effects to taking aspirin, Bilchik advised readers to focus on other ways they can help lower their colorectal cancer risk.
An important salicylate drug is aspirin, which has a long history. Aspirin intolerance was widely known by 1975, when the understanding began to emerge that it is an adverse drug reaction, not an allergy. [6] [7]
Hypersensitivity reactions are idiosyncratic reactions to a drug. [1] Although the term NSAID was introduced to signal a comparatively low risk of adverse effects, [2] NSAIDs do evoke a broad range of hypersensitivity syndromes. These syndromes have recently been classified by the European Academy of Allergy and Clinical Immunology Task Force ...
Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduces leukocyte adhesion, which is an important step in immune response to infection. There is currently insufficient evidence to show that aspirin helps to fight infection. [18]
These hypersensitivity reactions differ from the other adverse reactions listed here which are toxicity reactions, i.e. unwanted reactions that result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual; hypersensitivity reactions are idiosyncratic reactions to a drug. [98]