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Methylxanthines are chemical compounds which are derivatives of xanthine with one or more methyl groups, including: One methyl group: 1-Methylxanthine;
7-Methylxanthine (7-MX), also known as heteroxanthine, is an active metabolite of caffeine (1,3,7-trimethylxanthine) and theobromine (3,7-dimethylxanthine). [ 1 ] [ 2 ] It is a non-selective antagonist of the adenosine receptors .
Xanthine (/ ˈ z æ n θ iː n / or / ˈ z æ n θ aɪ n /, from Ancient Greek ξανθός xanthós ' yellow ' for its yellowish-white appearance; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most human body tissues and fluids, as well as in other organisms. [2]
IBMX (3-isobutyl-1-methylxanthine), like other methylxanthine derivatives, is both a: competitive non-selective phosphodiesterase inhibitor [1] which raises intracellular cAMP, activates PKA, inhibits TNFα [2] [3] and leukotriene [4] synthesis, and reduces inflammation and innate immunity, [4] and; nonselective adenosine receptor antagonist. [5]
Methylxanthines are not routinely used owing to their adverse effect profiles and the risk of toxicity. Adverse effects of Methylxanthines include nervousness , insomnia , irritability , anxiety , gastrointestinal disturbance (nausea, vomiting), tremor , palpitation and increased urine output.
Wagons East (sometimes styled as Wagons East!) is a 1994 American Western adventure comedy film directed by Peter Markle, written by Matthew Carlson, and starring John Candy, Richard Lewis, John C. McGinley, Ellen Greene, Robert Picardo, Rodney A. Grant, and Ed Lauter.
An interesting off-label indication of pentoxifylline is the supportive treatment of distal diabetic neuropathy, where it can be added, for example, to thioctic acid or gabapentin. [17] Theoretically, it can (among other things) act prophylactically against ulcerative changes of the lower limbs associated with chronically decompensated diabetes.
It Seemed Like a Good Idea at the Time is a Canadian comedy film, directed by John Trent and released in 1975. [1] One of John Candy's earliest films, he plays the minor role of an investigating police officer. However, for marketing/publicity reasons, Candy appears on the cover of the DVD release.