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Salt poisoning sufficient to produce severe symptoms is rare, and lethal salt poisoning is possible but even rarer. The lethal dose of table salt is roughly 0.5–1 gram per kilogram of body weight. [1] In medicine, salt poisoning is most frequently encountered in children or infants [2] [3] who may be made to consume excessive amounts of table ...
Bismuth sulfide is a highly insoluble black salt, and the discoloration seen is temporary and harmless. Long-term use (more than six weeks) may lead to accumulation and toxicity. [ 8 ] High daily intake over a period of months can possibly cause severe fatigue, weakness and neurological symptoms that reverse with discontinuation. [ 9 ]
The risk of hypotensive symptoms, such as dizziness, may also increase in some people, with moderate certainty. [76] It is unclear whether this affects the dosage required for anti-hypertensive medications. The effect of salt restriction on extracellular fluid, oedema, and total body weight reduction is also uncertain. [76]
Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
Severe symptoms include confusion, muscle twitching, and bleeding in or around the brain. [ 1 ] [ 2 ] Normal serum sodium levels are 135–145 mmol/L (135–145 mEq/L ). [ 5 ] Hypernatremia is generally defined as a serum sodium level of more than 145 mmol/L. [ 3 ] Severe symptoms typically only occur when levels are above 160 mmol/L. [ 1 ]
The US label for sodium oxybate has a black box warning because it is a central nervous system depressant (CNS depressant) and for its potential for abuse.Other potential adverse side effects include respiratory depression, seizures, coma, and death, especially when it is taken in combination with other CNS depressants such as alcohol.
Megestrol acetate is used mainly as an appetite stimulant to promote weight gain in a variety of situations. [25] [26] [27] When given at very high dosages, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. [25]
On a consumer level, salt substitutes, which usually substitute a portion of sodium chloride content with potassium chloride, can be used to increase the potassium to sodium consumption ratio. [40] This change has been shown to blunt the effects of excess salt intake on hypertension and cardiovascular disease.