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2. GTP-binding protein regulators - Wikipedia

   en.wikipedia.org/wiki/GTP-binding_protein_regulators

   The inactive form of GTPases (GDP-form) are activated by a class of proteins called Guanosine nucleotide exchange factors (GEFs). GEFs catalyse nucleotide exchange by encouraging the release of GDP from the small GTPase (by displacement of the small GTPase-associated Mg 2+ ion) and GDP's replacement by GTP (which is in at least a 10-fold excess within the cell) .

3. Dog health - Wikipedia

   en.wikipedia.org/wiki/Dog_health

   The lethal dose for 50% of dogs is 100 – 200 mg per kilogram (kg) of body weight, yet some dogs will exhibit signs of toxicosis after ingesting as little as 20 mg per kg. [38] In case of accidental intake of chocolate, especially involving a smaller dog, contact a veterinarian or animal poison control immediately; it is commonly recommended ...

4. GTPgammaS - Wikipedia

   en.wikipedia.org/wiki/GTPgammaS

   GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP). Many GTP binding proteins demonstrate activity when bound to GTP, and are inactivated via the hydrolysis of the phosphoanhydride bond that links the γ-phosphate to the remainder of the nucleotide, leaving a bound guanosine ...

5. Are harnesses bad for dogs? The pros and cons ... - AOL

   www.aol.com/harnesses-bad-dogs-pros-cons...

   What are the pros of dog harnesses? 1. Better control. Some harnesses can provide better control. If you have a well-fitted ‘Y’ shape harness, which has a double D-ring that attaches to a ...

6. Guanosine triphosphate - Wikipedia

   en.wikipedia.org/wiki/Guanosine_triphosphate

   Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside , the only difference being that nucleotides like GTP have phosphates on their ribose sugar.

7. GTPase - Wikipedia

   en.wikipedia.org/wiki/GTPase

   Hydrolysis of GTP bound to an (active) G domain-GTPase leads to deactivation of the signaling/timer function of the enzyme. [2] [3] The hydrolysis of the third (γ) phosphate of GTP to create guanosine diphosphate (GDP) and P i, inorganic phosphate, occurs by the S N 2 mechanism (see nucleophilic substitution) via a pentacoordinate transition state and is dependent on the presence of a ...

8. Monty the giant schnauzer wins Westminster dog show - AOL

   www.aol.com/dogs-great-danes-terriers-head...

   The jowly breed was developed to be an imposing guard dog, but Brina's owner, Yves Belmont, Ph.D., said he also is impressed by its intelligence. He keeps several of the dogs at his Atlanta-area home.

9. Weighing the Pros & Cons of 4 Common ED Pills - AOL

   www.aol.com/weighing-pros-cons-4-common...

   Over the last 25 years, (ED) medications such as Viagra and others have become common and normal pieces of bedroom tool kit. These little pills have helped hundreds of millions of men all over the ...