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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to target a particular molecular structure; biological (bDMARD) can be further separated into original and biosimilar DMARDs (boDMARDs and bsDMARDs)
Leflunomide This page was last edited on 22 December 2022, at 19:21 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional ...
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This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.
Leflunomide is an isoxazole-derivative drug. Examples of AAS containing the isoxazole ring include danazol and androisoxazole. A number of pesticides are isoxazoles. [10] Isoxaben is an example of an isoxazole used as a herbicide.
English: The process of in vivo activation of leflunomide (an immunosuppressive antirheumatic drug Arava) to its one and only active metabolite teriflunomide (an immunosuppressant to treat multiple sclerosis, sold under the brand name Aubagio). Created with ChemDoodle 7.0.2 and Adobe Illustrator CC.
Description: Skeletal formula of leflunomide.Created using ACD/ChemSketch 12.0 and Inkscape.Optimized with vim.: Date: 16 October 2010: Source: Own work, after ...